正常妊娠ならびに妊娠中毒症における一酸化炭素ヘモグロビン

概要

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It has been reported that normal and abnormal pregnancies are associated with some hemorheological changes, i. e. reduction of whole blood viscosity and red cell filterability in normal pregnancy and increase of whole blood viscosity in preeclampsia. To clarify the relation between such hemorheological changes and hemolysis, carboxyhemoglobin (HbCO) levels measured with spectrophotometry and red cell filterability were studied in normal pregnancy, puerperium and preeclamptic pregnancy. The HbCO levels of 21 normal pregnant women from 20 to 31 weeks of gestation and 27 normal pregnant women from 32 to 35 weeks of gestation were 2.47 ± 2.22% and 2.03 ± 1.29 % (M±SD) respectively, and were significantly higher as compared with nonpregnant one (1.21 ± 0.89 %) (p<0.05). The HbCO level of 36 normal pregnant women in 36 weeks or later of gestation was decreased to 1.72 ± 1.49%. On 3 days after delivery, HbCO was increased to a significant higher level (2.00 ± 0.92 %) as compared with nonpregnant one. In the 6 preeclamptic patients from 32 to 35 weeks of gestation, HbCO (3.24 ±1.67 %) was significantly higher than that of normal pregnant women at same weeks of gestation (P<0.05). There was a significantly inverse correlation between red cell filterability and HbCO, to be given by the correlation coefficient -0.452.
特定非営利活動法人日本バイオレオロジー学会の論文