Histopathological Changes in Parotid and Submandibular Glands of Patients Treated with Preoperative Chemoradiation Therapy for Oral Cancer

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概要

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• We retrospectively evaluated the relationship between computed tomography (CT)- and histopathological findings of parotid and submandibular glands in six patients treated for advanced oral cancer. Eligibility criteria were a pathologic diagnosis of oral squamous cell carcinoma, preoperative chemoradiation therapy (CRT) with a total dose of 30 Gy and oral S-1 (80 mg/m2/day), the availability of morphological assessments by CT and of functional assessments with the Saxon test before- and 2 weeks after CRT, and the availability of histopathological slides of irradiated parotid and submandibular glands. In the histopathological interpretation, gland structures were divided into acinar-, duct-, and adipose cells and other tissues. The Mann-Whitney test and the Spearman rank correlation test were used to determine histopathological changes. After 30-Gy irradiation, saliva production and parotid and submandibular volumes were significantly decreased (P < 0.05 each). Histopathological analysis demonstrated that 30-Gy irradiation resulted in a loss of acinar cells although acinar cells in the submandibular gland were relatively retained; the median acinar rate in the parotid and submandibular glands was 1.1% and 19.0%, respectively. The CT values after CRT were inversely correlated with adipose ratios (r = –0.98, P < 0.01) and there was a strong correlation between CT values before and after CRT (r = 0.97, P < 0.01). Our results suggested that acinar cell loss is a main contributor to changes in the volume and function of irradiated human parotid and submandibular glands. The CT value may reflect the adipose ratio rather than salivary function.

• Journal of Radiation Research 編集委員会の論文

著者

• Hirai Toshinori

  Department Of Radiology Amakusa Medical Center

• Yoshida Ryoji

  Department Of Internal Medicine Saiseikai Utsunomiya Hospital

• Yamashita Yasuyuki

  Department Of Diagnostic Imaging Faculty Of Medical And Pharmaceutical Sciences Kumamoto University

• Furusawa Mitsuhiro

  Department Of Radiology Kumamoto University School Of Medicine

• Nakayama Hideki

  Department Of Oral And Maxillofacial Surgery Kumamoto University Graduate School Of Medical Sciences

• Shinohara Masanori

  Department Of Dentistry And Oral Surgery Kumamoto University School Of Medicine

• Murakami Ryuji

  Department Of Radiation Oncology Graduate School Of Medical Sciences Kumamoto University

• TESHIMA Keiko

  Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University

• HIRAKI Akimitsu

  Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University

• NAKAGUCHI Yuji

  Department of Radiological Technology, Kumamoto University Hospital

• TSUJITA Naoko

  Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University

• TOMITAKA Etsushi

  Department of Radiology, National Hospital Organization Kumamoto Medical Center

• SHINOHARA Masanori

  Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University

• MURAKAMI Ryuji

  Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University

• NAKAYAMA Hideki

  Department of Oral and Maxillofacial Surgery, Faculty of Life Sciences, Kumamoto University

• FURUSAWA Mitsuhiro

  Department of Radiology, Kumamoto City Hospital

• HIRAI Toshinori

  Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University

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