Estimation of 123I-IMP arterial blood activity from dynamic planar imaging of the chest using a graph plot method for the quantification of regional cerebral blood flow
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概要
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Purpose: I-123 labeled N-isopropyl-p-iodoamphetamine(123I-IMP) is used for measurement of regional cerebral blood flow(rCBF). A continuous or single arterial blood sampling(ABS) is necessary to estimate an integral of arterial input function(AIF) for the measurement of rCBF by using a microsphere model analysis. Therefore, the method to measure rCBF without any blood sampling is desired. The aim of this study was to establish the method to estimate the AIF from the time-activity curve of the lungs after the injection of 123I-IMP using a regression analysis for the measurement of rCBF without any blood sampling. Materials and methods: Thirty-seven prospective studies in 10 consecutive patients were enrolled. A chest planar dynamic imaging for 3 minutes and continuous ABS for 5 minutes after a bolus injection of 167MBq 123I-IMP were performed in all studies. Data from the chest imaging were analyzed in comparison with ABS data(AIF(5)) in the first 10 studies, and an equation for estimation yielding accurate AIF(5) from the total counts cleared from the lungs during 5 minutes after injection of 123I-IMP(TCL(5)) was derived. The validity of the proposed method was evaluated in the subsequent 27 studies.Results: A good correlation was obtained between the AIF and TCL by regression analysis in the first 10 studies(r=0.94, p<0.001). An equation for the estimation of AIF by the regression analysis in the first 10 studies was defined as follows, estimated AIF=2146.7336 +4.1735xTCL(5). In the subsequent 27 studies, a good linear correlation was obtained between measured AIF(5) and estimated AIF(5) by using the equation(r=0.79, p<0.001). Conclusion: AIF(5) can be accurately estimated from the TCL(5). Therefore, estimated AIF(5) can be used for the measurement of rCBF instead of ABS data.
- THE JAPANESE SOCIETY OF NUCLEAR MEDICINE,日本核医学会の論文
- 2010-06-01
著者
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冨口 静二
熊本大学放射線科
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山下 康行
熊本大学医学部放射線医学教室
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Yamashita Yasuyuki
Department Of Radiology Kumamoto University
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Yamashita Yasuyuki
熊本大学 医学薬学研究部放射線診断学
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Yanaga Yumi
熊本大学 医学薬学研究部放射線診断学
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KAWANAKA Koichi
Department of Diagnostic Radiology, Kumamoto University Graduate School of Medical Sciences
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冨口 静二
熊本大学医学部附属病院 放射線科
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山下 康行
熊本大学 大学院放診
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冨口 静二
熊本大学 大学院医学薬学研究部放射線診断学部門
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Shiraishi Shinya
Department of Radiology, Kumamoto University
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TOMIGUCHI Seiji
Department of Diagnostic Radiology, School of Health Sciences, Kumamoto University
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SOMA Tsutomu
Clinical Application Technology Department, FUJIFILM RI Pharma Co., Ltd.
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山下 康行
熊本城医療センター
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Yoshida Morikatsu
Department of Biochemistry, National Cardiovascular Center Research Institute
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Yamaguchi Yasuo
Department Of Surgery Ii Kumamoto University Medical School
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Soma Tsutomu
Clinical Application Technology (cat) Group Daiichi Radioisotope Laboratories
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Soma Tsutomu
Department Of Medical Engineering Division Of Applied Health Sciences Osaka University Medical Schoo
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山下 康行
熊本大学医学部放射線科
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山下 康行
熊本大 医 放射線医学
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冨口 静二
熊本大学 医学部神経内科
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Tomiguchi Seiji
Department Of Diagnostic Radiology School Of Health Sciences Kumamoto University
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Kawanaka Koichi
Department Of Diagnostic Radiology Graduate School Of Medical Sciences Kumamoto University
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Tomiguchi Seiji
Department Of Radiology Kumamoto University School Of Medicine
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Shiraishi Shinya
Department Of Diagnostic Radiology Graduate School Of Medical Sciences Kumamoto University
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Yoshida Morikatsu
Department Of Biochemistry National Cardiovascular Center Research Institute
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Yamashita Yasuyuki
Department Of Diagnostic Imaging Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Tomiguchi Seiji
Department Of Radilogy Kumamoto University School Of Medicine
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TASHIRO KUNIYUKI
Department of Diagnostic Radiology, Graduate School of Medical Sciences, Kumamoto University
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Kawanaka Koichi
Department Of Diagnostic Imaging Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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TAKAHASHI Yoshitake
Clinical Application Technology Department, FUJIFILM RI Pharma Co., Ltd.
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Takahashi Yoshitake
Clinical Application Technology Department Fujifilm Ri Pharma Co. Ltd.
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Yamashita Yasuyuki
Department Of Diagnostic Radiology Kumamoto University Postgraduate School
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Tashiro Kuniyuki
Department Of Diagnostic Imaging Faculty Of Medical And Pharmaceutical Sciences Kumamoto University
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Soma Tsutomu
Clinical Application Technology Department Fujifilm Ri Pharma Co. Ltd.
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Shamima Sultana
Department Of Diagnostic Imaging Kumamoto University Graduate School Of Medical Sciences
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Yamaguchi Yasuo
Department Of Diagnostic Radiology Graduate School Of Medical Sciences Kumamoto University
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Yoshida Morikatsu
Department Of Diagnostic Imaging Kumamoto University Graduate School Of Medical Sciences
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Tomiguchi Seiji
Department Of Radiology Kumamoto Unviersity School Of Medicine
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Seiji Tomiguchi
Department of Diagnostic Radiology, School of Health Sciences, Kumamoto University
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Kuniyuki Tashiro
Department of Diagnostic Imaging, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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Shinya Shiraishi
Department of Diagnostic Imaging, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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Morikatsu Yoshida
Department of Diagnostic Imaging, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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Koichi Kawanaka
Department of Diagnostic Imaging, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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Yoshitake Takahashi
Clinical Application Technology Department, FUJIFILM RI Pharma Co., Ltd.
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Tsutomu Soma
Clinical Application Technology Department, FUJIFILM RI Pharma Co., Ltd.
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Yasuyuki Yamashita
Department of Diagnostic Imaging, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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