低分子デキストランの血液所見に及ぼす影響について

概要

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The low molecular weight dextran (L. M. D) has recently been developed for a wide clinical use in the treatment of hemorrhagic shock as a substitute for the blood when it is notavailable. The influence of L. M. D to the hematological findings was investigated and the following results and conclusions were obtained. 1. L. M. D. produced plasma volume expansion for only an hour or so following the inf ussion. 2. L. M. D. was inferior to mannitol in regard to compulsory diuretic effects. 3. L. M. D. prolonged the bleeding time, however, its effects on the coagulation system still remained to be studied further. 4. The peripheral circulation appeared to be favorably influenced by L. M. D. 5. Rapid infusion of L. M. D. in patients with normovolemia might cause circul-atory overload. 6. After infusion of L. M. D., it is excreted earlier and the specific gravity of the urine remarkably increased, while excretion of Na. K, and Cl. decreased.
学校法人昭和大学・昭和医学会の論文