前投薬としてのSodium γ-Hydroxybutyrateの使用経験について

概要

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Sodium γ-Hydroxybutyrate (OBA) was used as premedicants and the clinical effects were studied. Patients in relatively good risk, aged between 13 and 69, who had no association of illness, were selected for study at random. These patients were divided into three groups. The first group, the second group and the third group were given OBA 10-20 milligram per kilogram, OBA 66 milligram per kilogram and the placebo respectively. Each drugs were administered orally 1 1/2 hour prior to anesthesia induction and other no drugs combined. The effects were as follows;<BR>(1) In the first group, sedative effects were not evident. But 91.2 per cent in the second group were good sedated and there was no effect in the third group.<BR>(2) In the second group, patients exhibited many side effects such as exhausted feeling, heaviness in head, vertigo, nausea, headache, salivary secretion etc. It seemed that these side effects were mitigated by the combination with other drugs. For example, parasympathomimetic action was ameliorated with addition of belladonna.<BR>(3) There were no significant changes in blood pressure, pulse rate, ECG and minute volume.<BR>(4) The EEG pattern in subjects administering 66 milligram per kilogram of OBA resembled to those with natural sleeping pattern.
学校法人昭和大学・昭和医学会の論文