CMX耳用液の化膿性中耳炎に対する基礎的・臨床的検討

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A study was made of the efficacy and safety of a new cephalosporin antibiotic, Cefmenoxime (CMX) Otic Solution for purulent otitis media.1. Clinically, the topical administration of 0.5% CMX into the tympanic cavity was effective in 70.0% of the patients, bacteria were eradicated in 80.0% and the usefulness rate was 70.0%, while, 1.0% CMX was effective in 85.7%, bacteria were eradicated in 92.9% and the usefulness rate was 92.9%. The results were therefore satisfactory.2. CMX had quite a broad spectrum: very effective against gram-positive bacteria, and also effective in complex infections due mainly to gram-negative bacteria and anaerobic bacteria which are usually resistant to other medications.3. CMX solution was instilled into the tympanic cavity of guinea-pigs, and electrocochleographic and ultramicro morphological changes were evaluated. It was confirmed that CMX produced no cochlear toxicity in contrast to Gentamicin.4. The results of those experimental and clinical studies indicate that. CMX Otic Solution may be a very effective and safe topical agent.
耳鼻咽喉科臨床学会の論文