実験的副鼻腔炎に対するセアプロ-ゼSの治療効果--光顕的ならびに走査電顕的観察成績(教室〔鹿児島大学耳鼻咽喉科学教室〕最近3年の歩み記念論文)

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Experimental sinusitis was produced by repeated injection of the staphylococcus aureus 209 P strain in the maxillary sinus of 25 rabbits three times a week. They were then sensitized with the intramaxillary administration of 2.5% egg albumin.The animals in this study were divided into the following four treatment groups: group 1 was composed of three rabbits which received the inactive Seaprose; group 2, five animals were given Serratiopeptidase in a dose of 20mg/kg; and group 3 and 4 consisted of the animals which were treated with Seaprose in a dose of 40mg/kg in 5 cases and in a dose of 60mg/kg in 12 cases, respectively.The subjects in each group were given the above drugs through a gastric tube once a day for a period of two weeks. The macroscopic and morphological changes of the mucous membrane of the sinus of each experimental group were compared.The results obtained were as follows.In groups 1 and 2, a decreased number of cilia, abnormal giant cilia and abundant secretory cells were observed, but these pathologic changes were less prominent in groups 3 and 4. Seaprose demonstrated superior efficacy on the mucosal pathology of sinusitis in group 4. Moreover, there was a clearly significant difference between group 4 and the other three groups.From the above results, Seaprose was considered to be a useful enzyme for some kinds of sinusitis.