鼻副鼻腔悪性黒色腫に対する凍結手術と免疫療法の経験

概要

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Two patients with primary malignant melanoma originating in the nose and paranasal sinus were treated with combined cryosurgery and immunotherapy using a new immunopotentiator consisting of the cell-wall skeleton of Nocardia rubra (N-CWS).The first was a 45 year old man with complaints of left nasal obstruction and nasal discharge. Initially, BCG immunotherapy by local injection to the nasal tumor was carried out, but following the second injection, the patient went into a state of shock. The combined treatment with cryosurgery and immunotherapy using N-CWS was then begun.One month after the treatment, the nasal tumor was reduced considerably, and almost disappeared in two months. There are no signs of metastasis or local recurrence.The second case was a 71 year old woman who complained of swelling and pain in the left upper jaw. She had been given 60Co irradiation, but it was not effective.The same combined therapy mentioned above was begun, but she was discharged three weeks later as she and her family rejected further therapy.There is no evidence of metastasis of the tumor in this patient 8 months after the treatment. Thus, the combined therapy with cryosurgery and immunotherapy using N-CWS, a new immunopotentiator, shows promise for either operable or inoperable patients with a malignant melanoma in the upper respiratory tract.
耳鼻咽喉科臨床学会の論文