鼻副鼻腔粘膜の炎症とアラキドン酸カスケ-ド代謝物

概要

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Arachidonic acids released from phospholipids in cellular membrane are converted to various leukotrienes (LTs) by lipoxygenase as well as being transformed into different kinds of prostaglandins (PGs) by cyclooxygenase. LTs and PGs are known to play an important role in allergy and inflammation.Therefore the presence of LTs and PGs was examined in the retention fluids in maxillary cysts, the nasal secretion in nasal and paranasal mucosa and polyps obtained at the time of nasal and sinus operation.The predominant arachidonic acid metabolites in both nasal secretion of nasal allergy and chronic sinusitis were LTD4, 12-HETE, PGE2 and 6-Keto PGF1α.The levels of 5-HETE, 15-HETE and LTB4 were higher in nasal mucosa of hypertrophic rhinitis and sinus mucosa of chronic sinusitis than in nasal mucosa of allergic patients and nasal polyps.The levels of PGE2, 6-Keto PGF1α and TXB2 in nasal mucosa of allergic subjects were higher than those in nasal or sinus mucosa in non-allergic subjects.These results may help to understand the biochemical basis of the pathogenesis of chronic sinusitis and nasal polyps.
耳鼻咽喉科臨床学会の論文