An experimental study of wound healing and saliva in mice.

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Generally, a mouth wound heals faster than one in any other region of the body. Biological factors in saliva, such as kallikrein, amilase, lysozyme, immuno-globulin, renin, nerve growth factor and epidermal growth factor may influence wound healing-that is epithelialization, contraction, collagen synthesis, and scar remodelling. In this paper, we report the effect of saliva to the standard sacral open wounds of mice, varied with the caging method as follows: group 1: wounded mouse caged in isolation. group 2: two wounded mice caged together. group 3: wounded mouse caged with mouse priorly sialectomized (Sublingual and submandibular gland). The wound area was measured every 7 days after surgery. We obtained the results as follows: 1. We realized significant differences in each group. These findings suggest that biological factors in saliva accelerate wound healing. 2. Difference in the wound healing process between groups 2 and 3 suggests that the amount and characterization of saliva effect on the wound contraction.
社団法人日本口腔外科学会の論文