Effect of minocycline on cultured cells from oral tissue.

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Although numerous studies have been reported concerning the antimicrobial properties of minocycline, inhibition of neutrophil function by minocycline has recently been the focus of a number of investigations. However, the effect of minocycline on fibroblast function is not clearly understood. Cell proliferation and fibroblast migration are basic biological processes in wound healing. We therefore investigated the influence of minocycline on cell proliferation and migration, using two cell lines derived from oral tissue (gingival fibroblast, palatal mesenchyme). The following results were obtained: 1. Minocycline inhibited cell migration dose-dependently. 2. Minocycline inhibited cell proliferation. 3. We surmised that this inhibition of cell function was due to the ability of minocycline to bind to Ca2+ in the medium.
社団法人日本口腔外科学会の論文