骨形成蛋白(BMP)の骨膜代用材としての応用 : ヒト大腿筋膜(SolVent Dehydrated Human Fascia Lata)との併用

概要

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The purpose of the present study is to investigate the osteogenesity of the Solvent Dehydrated Human Fascia lata (FL)- half purified bone morphogenetic protein (BMP) composite membrane as a periosteum substitute. One mg of BMP extracted from bovine bone matrix was applied on the surface of the membrane. A 6mm diameter hole was drilled and surrounding periosteum removed from the femur of a Japanese white rabbit. The bone defects were covered with FL-BMP and FL membrane. Four week and twelve week after implantation, all animals were sacrificed and the specimens were observed histologically. The results demonstrated that the FL-BMP membrane was incorporated with a new bone tissue, and that the bore ciontours of th defect were healed normally. In contrast no bony incorporation of the material was observed in the FL membrane. It is suggested that Fascia lata is as ideal as the natural collagenous carrier of BMP and that this composite is useful in bone reconstruction as a periosteum substitute.
硬組織再生生物学会の論文