BMPの担体に関する研究 : 多糖類-BMP複合体の骨形成について

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Bond morphogenetic protein (BMP) is known as a protein which induces new bone at heterotopic sites. Purification of BMP has not been perfected, and obtaining large amounts of BMP is very difficult, so it seems better to use some carrier or frame material for BMP to work effctively. Various kind of Calcium phosphate, collagen, gelatin were aften appliedas carriers of BMP, but they sometime show problems. For instance carriers remain in the tissue after new bone formation occurred, and on the other hands, some carriers are so quickly absorbed that there is not enough time to show the effect on BMP. It is now very important to control the speed of absorption of carriers. Recently, the denatured starch that was reduced by enzyme is often used for medical treatment. The objective of this report is to estimate the capability of starch as a carrierof BMP. BMP was extracted from bovine cortical bones according to the Urist's procedure. The denatured starch (pinedex) used in this study was supported to Matutani chemical industry corporation Ltd. and there were different molecular weight of Pinedex. The BMP-starch complex was implanted in the muscle pouch of mice, then osteoinduction was examined 20 days after implantation. Furthermore, absorption speed of each starch immersed in the artificial extra cellular fluid was examined. New bone formation was studied by quantitative computation, and roentgenographic/histologic observation was also studied. The BMP-starch complex group showed good biological compatibility by histological view and the new bone formation was confirmed on the roentgenograms. Most beneficial molecular weight is abouto650, and it's absorption speed is approximately 30 minutes in artificial extra cellular fluid.
硬組織再生生物学会の論文
1995-11-10

BMPの担体に関する研究 : 多糖類-BMP複合体の骨形成について

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