BMPを付与した電気化学的表面改質Ti及びHA-G-Ti複合材料の骨形成能

概要

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Eight kinds of specimens were prepared by combinations of substrates (titanium and HA-G-Ti composite), with and without electrochemical surface modification, and with and without bone morphogenetic protein (BMP). Each specimen was implanted in the muscle pouch ofddY-mouse . Ten specimens were used for each group. At 3 weeks after implantation, new bone formation was quantitatively analyzed by a computer-area analysis through Roentgenograph, and qnalitatively evaluated with histological observations, All groups showed good biological compatibility by histological observations. Both the incident rate and total amount of new bone formation of the HA-G-Ti were higher than with titanilan, and those of titanium with the electrochemical surface modification were higher than specimens without it. However, there was no significant difference in the amount of new bone formation between the four groups coated with BMP. These results suggested that, although the electrochemical surface modification and HA-G coating had no effect on the osteoinductive ability of BMP, these treatments can inerease the containing rate of BMP around implant. It is concluded that the adsorption of BMP on specimens depends strongly on the geometric and chemical properttes of the surface area.
硬組織再生生物学会の論文