AAN Effect on Epiphyseal Growth Plate in Hypophysectomized Rats

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Experimental osteolathyrism was produced by Aminoacetonitrile (AAN) in hypophysectomized rats. This experiment could reveal the effect of lathyrogen on the epiphseal growth plate under the condition, in which proliferation and maturation of the cartilage cells were ceased.Young rats of Wistar strain, weighing about 50gm, were hypophysectomized. The rats were daily treated with subcutaneous injection of Aminoacetonitrile hydrogen sulfate 0.2-0.25mg/gm. The proximal part of the tibia was sectioned for histological study of the plate.Histologically the cells in cartilage column of the plate were enlarged, vacuolated, irregularly arranged and intercellular spaces were widened. These findings means that AAN accelerate maturation and degeneration of the chondrocytes. The cartilage matrix in the plate showed a considerable degree of edema, but was not enough resorbed in the layer of provisional calcification if the cells were fully degenerated. These findings indicated that the maturation and resorption of the cartilage matrix were disturbed by AAN. In the osteolathyrism of hypophysectomized rats prolifetation of the cells was not observed. The increasing in width of the plate in osteolathyrism was not owing to hyperplasia of the cells, but owing to the disturbed resorption of the cartilage matrix.Our observations indicated that AAN delayed the maturation of the cartilage matrix, but had no effcet on the proliferation of the chondrocytes.
西日本整形・災害外科学会の論文

AAN Effect on Epiphyseal Growth Plate in Hypophysectomized Rats

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