The Effective Points of Steroid Hormone on Rheumatoid Arthritis

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The clinical and experimental studies had been performed in order to know the effective points of steroid hormone on rheumatoid arthritis. The methods were as follows:(1) The latex fixation test was examined using the human serum with rheumatoid arthritis, 68 years old, female, stage 3, class 4, classical.(2) The steroid hormone was added on it after the complete agglutination had been observed.(3) The patients' serum was incubated with steroid hormone at 37 C-degree for one hour and then the agglutination test was examined with the latex reagent.(4) The reaction between the 1/2 diluted latex reagent with the physiological salts solution and the serum was demonstrated as a control.(5) The latex test reagent was incubated with steroid hormone and then, the agglutination test was examined with the patients' serum.The results were as follows:In the reaction of (1), (2), (3) and (4), above mentioned, it showed the stronger agglutinating nature. But in the last reaction, in case of using the incubated latex reagent with the steroid hormone it was lesser agglutinated. This facts indicate the effectiveness of steroid hormone on rheumatoid arthritis are not only by the antiinflammatory nature, but also by the direct influences on antigenantibody reaction itself.
西日本整形・災害外科学会の論文