ポリビニルブチラール膜を用いるFETバイオセンサー

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The present review describes the FET-biosensor using polyvinylbutyral (PVB) membrane. The PVB membrane was applied to the surface of the silicon nitride which is the gate insulator of the IS-FET (Ion Sensitive Field Effect Transistor). The membrane exhibited good adhesive properties and was used for biomolecules immobilization, such as urease. H<SUP>+</SUP>-ATPase, etc.. The water content of the membrane was 27.6% with a thickness of 23, am. The surface structure of the membrane was observed by scanning electron microscopy, which revealed a regular porous microfilter arrangement with a mean pore diameter of 0.25 μm. Immobilized urease activity in this membrane was approximately 20% higher than when a urease-triacetylcellulose membrane was used. Using this polyvinylbutyral membrane, urea sensor, ATP sensor, acetylcholine sensor and HSA sensor were constructed. The new type device of ISFET was also constructed from amorphous silicon. From this device and PVB membrane, glucose sensor, hypoxanthine sensor and inosine sensor were constructed.