ヒト由来マイコプラズマとウイルスとのマウスへの混合感染実験

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At first, mycoplasmas which had been introduced into normal mice experimentally were tested for persistence. When Mycoplasma pneumoniae and M. orale were inoculated into mice intranasally they stayed in the lungs for 72 hours after inoculation. When M. salivarium and M. hominis were introduced intracerebrally, they were recovered 48 hours after inoculation. No mycoplasmas were detected, however, 24 hours after intraperitoneal inoculation.When the influenza virus WS strain was inoculated simultaneously with M. pneumoniae, the death rate (LD50) and minimal infectious value (MID50) increased among infected mice, as compared with those among mice infected with the WS strain alone. On the other hand, M. orale acted as a stimulator when the NWS strain was inoculated intranasally into mice.In the case of Japanese encephalitis virus (JEV) infection, an additional infection with mycoplasmas reduced the lethal dosis of JEV when the intracerebral inoculation route had been used. On the contrary, mycoplasmas stimulated the infectious activity of JEV when they had been introduced intranasally with the virus. The most stimulating effect was obtained when M. orale was inoculated 2 days after JEV infection by the intranasal route.In the case of mixed intracerebral infection with herpes simplex virus and mycoplasmas, no difference was seen in the lethal dosis between the virus in single infection and the virus and mycoplasmas in mixed infection.From the results mentioned above, it could be presumed that virus multiplication might be modified at the early stage by the presence of mycoplasmas, because mycoplasmas inoculated into normal mice were held in the body for a short time after inoculation. In future, however, an attempt should be made to isolate viruses and mycoplasmas in the course of experiment.
日本細菌学会の論文

ヒト由来マイコプラズマとウイルスとのマウスへの混合感染実験

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