EFFECT OF THIAMINE ON SEROTONIN OXIDATION IN MAGNESIUM-DEFICIENT RATS
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概要
- 論文の詳細を見る
To clarify the effect of thiamine on serotonin-related metabolism in magnesium-deficient rats, in vivo and in vitro experiments were carried out. In thiamine-excess magnesium-deficient and thiamine-adequate magnesium-deficient rats, serotonin oxidation activity in liver and stomach decreased significantly, while a decrease was not observed in thiamine-deficient magnesium-deficient rats. In vitro addition of a metal chelating agent and either thiamine or thiamine pyrophosphate to brain and liver mitochondria of intact rats resulted in a decrease in serotonin oxidation activities. Thus it is assumed that excess thiamine coupled with magnesium deficiency plays a role in the inhibition of serotonin oxidation and consequently serotonin increase.
- 財団法人 学会誌刊行センターの論文
著者
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糸川 嘉則
Department of Hygiene, Faculty of Medicine, Kyoto University
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木村 美恵子
Department of Pharmacology, Faculty of Medicine, Kyoto University
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稲垣 千代子
Department of Pharmacology, Faculty of Medicine, Kyoto University
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糸川 嘉則
Department Of Hygiene Faculty Of Medicine Kyoto University
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田中 千賀子
Department of Pharmacology, Faculty of Medicine, Kyoto University
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木村 美恵子
Department of Hygiene, Faculty of Medicine, Kyoto University
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