EFFECTS OF DICHLOROISOPROTERENOL AND PHENOXY BENZAMINE ON THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED RABBIT'S HEART
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory effects of α-receptor blocking agents such as dibenamine, yohimbine and chlorpromazine on the transmembrane potentials in the atria isolated from intact and reserpinized rabbits were reported previously (1-3). Although acetylcholine (ACh) as well as adrenaline and noradrenaline could restart the atrial action potential which had been ceased by the application of the adrenolytics, the restarting effect of ACh showed considerable differences from that of catecholamines. It was described by several investigators that positive inotropic and chronotropic responses of catecholamines in the mammalian heart were not prevented by α-receptor blocking agents (4) but were antagonized by dichloroisoproterenol (DCI), a β-receptor blocking agent (5, 6). In the isolated heart preparations, the stimulating effect of ACh was blocked by the pretreatment with DCI or by the full reserpinization of the animals (7-10). These results proposed the assumption that the stimulating effect of ACh derived from endogenously released catecholamine. However, as already confirmed in the previous report (2), the evidence that the addition of ACh could restart the action potential which had been ceased by the pretreatment of α-receptor blocking agents even in the reserpinized rabbit was against the afcre-mentioned assumption.<BR> In order to elucidate whether the stimulating effect of ACh derives from endogenously released catecholamine or not, the effects of ACh and catecholamine on the transmembrane potentials of the heart should be observed in relation to β-receptor blocking effects of DCI.<BR> The present experiments have been designed to compare the effects of DCI and phenoxybenzamine, an α-receptor blocking agent, on the atrial and ventricular transmembrane potentials in the isolated rabbit's heart, and to elucidate the correlation between the actions of DCI and ACh or catecholamines. Further, the effects of DCI and phenoxybenzamine on the conduction time and the effective refractory period of the ventricle have been comparatively studied.
- 公益社団法人 日本薬理学会の論文
著者
-
高折 修二
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
田中 千賀子
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
三須 良実
Department of Pharmacology, Faculty of Medicine, Kyoto University
関連論文
- EFFECTS OF PSYCHOTROPIC AGENTS ON THE EXPLORATORY BEHAVIOR OF RATS IN A Y-SHAPED BOX
- EFFECTS OF THIAMINE DERIVATIVES ON THE ATRIAL TRANSMEMBRANE POTENTIALS AND SPONTANEOUS CONTRACTION IN THE RABBIT
- EFFECTS OF PSYCHOTROPIC AGENTS ON SIDMAN AVOIDANCE RESPONSE IN GOOD- AND POOR-PERFORMED RATS
- EFFECTS OF AMINOPYRINE AND PHENYLBUTAZONE ON THE ACTIVITY OF NEURONS IN THE TRIGEMINAL NUCLEI AND HYPOTHALAMUS
- EFFECTS OF VOLATILE ANESTHETICS ON THE EVOKED POTENTIALS AND UNITARY DISCHARGES IN THE CENTRAL AUDITORY SYSTEM CAUSED BY CLICK STIMULI IN CATS
- EFFECTS OF CENTRAL DEPRESSANTS ON THE EVOKED POTENTIALS IN THE INFERIOR COLLICULUS CAUSED BY ACOUSTIC STIMULI IN THE CAT
- EFFECTS OF p-CHLOROPHENYLALANINE, A SEROTONIN DEPLETOR, ON SIDMAN AVOIDANCE RESPONSE IN RATS
- MODE OF ACTION OF CHLORPROMAZINE ON UNIT DISCHARGES FROM NUCLEAR STRUCTURES IN THE BRAINSTEM OF CATS
- ELECTROENCEPHALOGRAPHIC STUDIES ON THIAMINE DERIVATIVES IN THE RABBIT
- THE CENTRAL ACTION OF GAMMA-BUTYROLACTONE AND GAMMA-HYDROXYBUTYRATE
- EXPLANATION OF ATRIAL BIPHASIC RESPONSES TO ISOXSUPRINE IN THE RABBIT AND GUINEA PIG
- THE ACUTE PARTIAL FAILURE OF NEUROMUSCULAR TRANSMISSION BY RESERPINE IN THE ISOLATED PERFUSED RABBIT'S HEART
- EFFECT OF THIAMINE ON SEROTONIN OXIDATION IN MAGNESIUM-DEFICIENT RATS
- SPECIES DIFFERENCES OF SERUM AND LIVER CHOLESTEROL LEVELS BETWEEN RABBITS AND RATS FED ON HIGH-CHOLESTEROL DIET
- CENTRAL DEPRESSANTS AND EVOKED CLICK RESPONSES WITH SPECIAL REFERENCE TO THE RETICULAR FORMATION IN THE CAT
- CHRONIC ORAL TOXICITY OF 3, 5, 3'-TRIIODO-4'-ACETYLTHYROFORMIC ACID WITH SPECIAL REFERENCE TO CHOLESTEROLYTIC EFFECTS
- HISTOCHEMICAL DEMONSTRATION OF NORADRENALINE IN RAT SALIVARY GLANDS
- THE ANTAGONIZING MECHANISM OF ACETYLCHOLINE ON THE ATRIAL NON-PACEMAKER POTENTIALS DEPRESSED BY ADRENOLYTICS
- RECOVERING EFFECT OF ACETYLCHOLINE ON THE DEPRESSED ATRIAL TRANSMEMBRANE POTENTIAL OF THE RESERPINIZED RABBIT BY THE ADRENOLYTICS
- PHARMACOLOGICAL ANALYSIS OF UNITARY DISCHARGES RECORDED FROM THE INFERIOR COLLICULUS CAUSED BY CLICK STIMULI IN CATS
- EFFECTS OF CARNITINE ON THE SPONTANEOUS CONTRACTION AND THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED RABBIT'S ATRIA
- DEVELOPMENTAL ABNORMALITIES OF SKELETAL SYSTEM INDUCED BY ETHYLURETHAN IN THE RAT
- EFFECTS OF CENTRAL DEPRESSANTS ON THE CORTICAL AUDITORY RESPONSES IN THE UNRESTRAINED CATS
- EFFECTS OF COOLING AND WARMING OF THE COMMON CAROTID ARTERIES ON THE BRAIN AND TYMPANIC MEMBRANE TEMPERATURES IN THE RABBIT
- EFFECTS OF ADRENERGIC BLOCKING AGENTS ON THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED ATRIUM IN RABBITS
- EFFECTS OF CENTRAL DEPRESSANTS ON THE CORTICAL AUDITORY RESPONSES EVOKED BY REPETITIVE CLICK STIMULI IN THE CAT
- EFFECTS OF DICHLOROISOPROTERENOL AND PHENOXY BENZAMINE ON THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED RABBIT'S HEART
- EFFECTS OF CENTRAL DEPRESSANTS AND STIMULANTS ON EEG ALTERATIONS INDUCED BY CAROTID COOLING AND WARMING