EXPLANATION OF ATRIAL BIPHASIC RESPONSES TO ISOXSUPRINE IN THE RABBIT AND GUINEA PIG

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概要

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• Isoxsuprine, a vasodilator agent, 2-(3 phenoxy-2 propylamino)-1-(p-hydroxyphenyl)-1-propanol hydrochloride, was synthesized by Moed and Van Dijk in 1956 (1) and has a β-stimulatory and adrenolytic action and a papaverine-like or a direct action as reported by Brücke et al. (2) and Ariëns and Simonis (3). Lish et al. (4, 5) attributed a relaxing activity of the drug to the adrenergic β-stimulatory action in some tissues and the direct action in other tissues when different kinds of non-vascular smooth muscle were used. However, Drinnon and Yelnosky (6) and Manley and Lawson (7) reported that the vasodilator action of isoxsuprine was attributable mainly to the direct action of the drug. Preliminary observations showed atrial biphasic responses—initial stimulatory and then inhibitory responses—to a relatively high dose of isoxsuprine. This study was undertaken to investigate in details a mechanism of atrial biphasic responses to the drug in the rabbit and guinea pig.

• 公益社団法人 日本薬理学会の論文

著者

• 三須 良実

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University

• 久保 孝夫

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University

• 大塚 勝

  Research Laboratories, Pharmaceutical Division, Sumitomo Chemical Co., LTD.

• 坂手 実

  Department de Farmacologia, Faculdade de Ciencias Médicas e Biológicas de Botucalu

• 三須 良実

  Department of Pharmacology, Faculty of Medicine, Kyoto University

関連論文

• EFFECTS OF THIAMINE DERIVATIVES ON THE ATRIAL TRANSMEMBRANE POTENTIALS AND SPONTANEOUS CONTRACTION IN THE RABBIT
• A PHARMACOLOGICAL EVIDENCE FOR THE EXISTENCE OF INTRACARDIAC SYMPATHETIC GANGLIA IN THE RABBIT
• A POSSIBLE MECHANISM OF ARRHYTHMIA INDUCED BY 1-ADAMANTANAMINE
• EXPLANATION OF ATRIAL BIPHASIC RESPONSES TO ISOXSUPRINE IN THE RABBIT AND GUINEA PIG
• INTERACTION BETWEEN EXTRACELLULAR SODIUM AND THE EXCITATORY EFFECT OF ACETYLCHOLINE ON THE NON-PACEMAKER POTENTIAL ARRESTED BY PROPRANOLOL IN THE ISOLATED RABBIT'S ATRIA
• THE ACUTE PARTIAL FAILURE OF NEUROMUSCULAR TRANSMISSION BY RESERPINE IN THE ISOLATED PERFUSED RABBIT'S HEART
• THE ANTAGONIZING MECHANISM OF ACETYLCHOLINE ON THE ATRIAL NON-PACEMAKER POTENTIALS DEPRESSED BY ADRENOLYTICS
• RECOVERING EFFECT OF ACETYLCHOLINE ON THE DEPRESSED ATRIAL TRANSMEMBRANE POTENTIAL OF THE RESERPINIZED RABBIT BY THE ADRENOLYTICS
• EFFECTS OF CARNITINE ON THE SPONTANEOUS CONTRACTION AND THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED RABBIT'S ATRIA
• EFFECTS OF ADRENERGIC BLOCKING AGENTS ON THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED ATRIUM IN RABBITS
• EFFECTS OF DICHLOROISOPROTERENOL AND PHENOXY BENZAMINE ON THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED RABBIT'S HEART

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