Branched-chain .ALPHA.-ketoacids and related acids in thiamin-deprived rats.
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概要
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We showed elevated plasma levels of branched-chain amino acids, a-ketoacids, a-hydroxyacids in thiamin-deprived rats, which had decreased liver thiamin levels (2.4% of control) after 4 weeks of feeding of thiamin-deficient diet. The ratios of mean levels of these acids in thiamin-deficient rats to those in control rats were as follows: total branched-chain amino acids 1.6; total branched-chain α-ketoacids 2.7; total branched-chain a-hydroxyacids 3.6; pyruvic acid 1.6. The plasma level of total branched-chain a-hydroxyacids was correlated to liver thiamin concentration (γ=-0.67, p<0.01), but those of the other two acids were not correlated. Although the increased levels of branched-chain acids in thiamin-deprived rats were less remarkable than those of ill patients with maple syrup urine disease, they reflect the reportedly decreased branched-chain a-ketoacid dehydrogenase activities (about 40% of control), and we discussed whether the toxic effects of individual branched-chain acid could be demonstrated by its administration to the thiamin-deprived rats.
- 財団法人 学会誌刊行センターの論文
著者
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須藤 正克
Department of Pediatrics, Fukui Medical School
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糸川 嘉則
Department Of Hygiene Faculty Of Medicine Kyoto University
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重松 陽介
Department of Pediatrics, Fukui Medical School
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木川 芳春
Department of Pediatrics, Fukui Medical School
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