Delayed auditory brainstem response in thiamin-deficient rats.
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概要
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We recorded the auditory brainstem responses of rats fed a thiamin-deficient diet. The interpeak latencies between waves I and III, as well as those between waves I and IV, were significantly prolonged from day 24, while the latency of wave I was prolonged on day 26 of the thiamin-deficient diet. These delayed responses were corrected in 2 to 4 days after the initiation of daily intraperitoneal thiamin injections from day 32. The rats that were fed the thiamin-deficient diet, and then sacrificed on day 32, showed a decrease of total thiamin levels in the brain (26% of the level in control rat brains). Based on these results, we emphasize the value of the auditory brainstem response to detect thiamin deficiency.
- 財団法人 学会誌刊行センターの論文
著者
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須藤 正克
Department of Pediatrics, Fukui Medical School
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糸川 嘉則
Department Of Hygiene Faculty Of Medicine Kyoto University
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重松 陽介
Department of Pediatrics, Fukui Medical School
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木川 芳春
Department of Pediatrics, Fukui Medical School
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中井 昭夫
Department of Pediatrics, Fukui Medical School
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栗山 政憲
Department of Pediatrics, Fukui Medical School
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小西 行郎
Department of Pediatrics, Fukui Medical School
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