STUDIES ON MYOINOSITOL : X. EFFECTS OF CAFFEINE AND THEOPHYLLINE ON INCORPORATION OF MYOINOSITOL INTO PHOSPHATIDYLINOSITOL IN RAT LIVER HOMOGENATE
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概要
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Both caffeine and theophylline, which were known to be potent inhibitors of cyclic-AMP phosphodiesterase, stimulated the incorporation of myoinositol into phosphatidylinositol in rat liver homogenate. However, cyclic-AMP had no effect. The effect of dibutyrylcyclic-AMP differed with different concentrations. These results suggest that the stimulation cannot be explained by the increase in the amount of cyclic-AMP. This view was supported by the fact that papaverine, cyclic-AMP phosphodiesterase inhibitor, did not stimulate the incorporation and imidazole, the phosphodiesterase stimulator, did not inhibit the incorporation, and that adenylcyclase stimulators, epinephrine and glucagon, did not stimulate the incorporation.
- 財団法人 学会誌刊行センターの論文
著者
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西垣 郁雄
応用生化研
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西垣 郁雄
Institute of Biochemistry Faculty of Medicine, University of Nagoya
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奥村 ミサヲ
Institute of Biochemistry, Faculty of Medicine, University of Nagoya, Nagoya
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大浜 宏文
Institute of Biochemistry, Faculty of Medicine, University of Nagoya
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八木 国夫
Institute of Biochemistry, Faculty of Medicine, University of Nagoya
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西垣 郁雄
Institute of Biochemistry, Faculty of Medicine, University of Nagoya
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奥村 ミサヲ
Institute of Biochemistry, Faculty of Medicine, University of Nagoya
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