ミオイノシトールに関する研究 : (XIII)^3H-ミオイノシトールの脂肪肝ホスファチジルイノシトールへの取込み

概要

論文の詳細を見る
To approach the mechanism of lipotropic action of myoinositol, the incorporation of ^3H-myoinositol into phospholipid of the liver organelles was examined in normal and dietary fatty liver animals. ^3H-Myoinositol was found to be exclusively incorporated into phosphatidyl-inositol fraction in all the cases examined. The total incorporation of ^3H-myoinositol into phosphatidyl-inositol fraction in the fatty liver organelles was equal, if not higher, than that of the normal ones. This result shows that even in the fatty liver the phosphatidyl-inositol synthesizing enzymes are still intact in spite of the disturbance of lipoprotein synthesizing and secretion machinery as reported previously, and supports the view that the administered myoinositol promotes the synthesis of phosphatidyl-inositol and the repair of membranes which seem to contribute to the synthesis and secretion of β-lipoprotein of the liver, resulting in the lipotropic action.
日本ビタミン学会の論文
1971-11-25