ミオイノシトールにかんする研究 : (IX)ミオイノシトール大量投与の幼若シロネズミ肝臓内遊離および結合型イノシトールの動態におよぼす影響

概要

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When young rats were injected intraperitoneally with a large amount (40 mg/rat) of 2-^3H-myoinositol (1.5×10^5 cpm/mg), a temporal change in the concentration of free inositol was observed in the blood and its concentration in the liver rapidly increased to a level 1.5-2 times higher than the normal, which was maintained for fairly a long time. However, the change in the specific radioactivity of free inositol fraction was temporal in the liver, whereas it was duarable in the blood. In the liver microsomes was observed a rapid synthesis of radioactive phosphatidylinositol in the early stage after the injection, but it was not accumulated in these organelles. In mitochondria, production of such"transferable"phosphatidylinositol was not observed. From the viewpoint of the lipotropic nature of myoinositol, some discussions were made on the possible role of this"transferable"myoinositol producible in microsomes.
日本ビタミン学会の論文
1969-03-25