ビタミンB_2ニコチン酸エステルにかんする研究 : (V)シロネズミの脂肪肝発生時における肝の過酸化脂質濃度の上昇とビタミンB_2テトラニコチン酸エステル投与の影響

概要

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Increase in the peroxide value was found in both trichloroacetic acid-soluble and lipid fractions of the fatty liver, which was induced by massive doses of B-vitamins on rats previously stunted with low protein, high carbohydrate diet with no B-vitamins. Administration of choline and myoinositol prevented the accumulation of fats in the liver, as well as the increase in the peroxide values of both liver fractions, but at the same time, it seemed to induce the increase in the serum peroxide value due probably to the removal of fats from the liver. Although riboflavin and riboflavin-tetranicotinate showed no beneficial effect to prevent the development of fatty liver, they seemed to have some effect to prevent, the increase in peroxide values in the liver and in the serum. It was noted that by administration of lipotropic agents and riboflavin-tetranicotinate simultaneously both the fat accumulation in the liver and the increase in peroxide values in the liver and in the serum were markedly prevented.
日本ビタミン学会の論文
1968-05-25