ビタミンB_2テトラニコチン酸エステルにかんする研究 : (VIII)経口投与したビタミンB_2テトラニコチン酸エステルのニコチン酸部分の血流中への吸収と臓器NADへのとり込み

概要

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Rats were administered orally with B_2-Nic^<*1)>-^3H (only nicotinate moieties were uniformly labeled), and the incorporation of radioactivity into blood stream and into NAD of the kidney and the liver was investigated. A very slow increase in the specific radioactivity was observed with free NiA^<*2)>-^3H. After 30 hours of administration, however, the specific radioactivity of blood nicotinate of rats administered with B_2-Nic-^3H became higher than that of rats administered with NiA-^3H, suggesting the deposit type nature of the former compounds. The rate of incorporation of radioactivity of B_2-Nic-^3H into NAD of organs was also found to be slow as compared with the rate of incorporation of NiA-^3H. However, B_2-Nic-^3H was found to be superior to NiA-^3H in keeping the high level of specific radioactivity of hepatic and renal NAD for a long time.
日本ビタミン学会の論文
1969-06-25