Metabolism of injected flavins studied by using double-labeled [14C]flavin adenine dinucleotide and [14C, 32P]flavin mononucleotide.
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概要
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The metabolism of flavins in mouse was studied with [F-(2)-14C, A-(2, 8)-14C] FAD and [F-(2)-14C, 32P] FMN. Ninety minutes after injection, radioactive isoalloxazine nucleus of double-labeled FAD was markedly incorporated into FAD, FMN and riboflavin in the liver, whereas a small amount of radioactive adenine nucleus of double-labeled FAD was found in FAD in the liver. In the case of FMN, radioactive isoalloxazine nucleus of double-labeled FMN was markedly incorporated into FAD, FMN and riboflavin in the liver, whereas only a minute amount of radioactive phosphorus was incorporated into FMN and FAD in the same organ. These results indicate that FMN and FAD injected are rapidly hydrolyzed and resynthesized in animal body.
- 財団法人 学会誌刊行センターの論文
著者
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奥田 潤
Department Of Clinical Biochemistry Faculty Of Pharmacy Meijo University
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八木 國夫
Institute Of Applied Biochemistry Yagi Memorial Park
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奥村 ミサヲ
Institute of Biochemistry, Faculty of Medicine, University of Nagoya, Nagoya
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長嶺 順子
Department of Clinical Biochemistry, Faculty of Pharmacy, Meijo University
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奥村 ミサヲ
Institute of Biochemistry, Faculty of Medicine, University of Nagoya
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