Effects of methionine and related compounds on plasma cholesterol level in rats fed a high cholesterol diet.

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概要

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• The comparative effects of methionine and its structurally and metabolically related compounds on plasma cholesterol level were investigated with rats fed a high cholesterol diet. The plasma cholesterol level was significantly enhanced by the dietary addition of methyl compounds such as L-methionine, D-methionine, choline and betaine. On the other hand, the intermediary metabolites of methionine such as homocystine, cysteine and 3-methylthiopropionate reduced plasma cho-lesterol. S-Methyl-L-cysteine and dimethylglycine had no significant effect. The plasma cholesterol-elevating effects of methionine, betaine and histi-dine were all prevented, more or less, by the concurrent addition of glycine to the diet, suggesting the existence of a common mechanism for their effects. The results support a possibility that the plasma cholesterol-elevating efficacy of methionine is attributable to its methyl group.

• 財団法人 学会誌刊行センターの論文

著者

• 村松 敬一郎

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture

• 杉山 公男

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka Unviersity

• 赤井 弘幸

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University

• 杉山 公男

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University

関連論文

• THE RELATIONSHIP BETWEEN WEIGHT GAIN AND FREE AMINO ACID CONCENTRATION OF PLASMA AND LIVER IN RATS FED A DIET SUPPLEMENTED WITH VARIOUS AMOUNTS OF LYSINE
• EFFECT OF SUPPLEMENTATION OF LIMITING AMINO ACIDS ON TYROSINE TOXICITY IN RATS FED WHEAT GLUTEN DIETS
• EFFECT OF INDIVIDUAL AMINO ACID SUPPLEMENTS ON THE TOXICITY OF EXCESS TYROSINE IN RATS
• BENEFICIAL EFFECT OF METHIONINE AND THREONINE SUPPLEMENTS ON TYROSINE TOXICITY IN RATS
• Self-selection of histidine and arginine intake and the requirements for these amino acids in growing rats.
• Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.
• Effects of methionine and related compounds on plasma cholesterol level in rats fed a high cholesterol diet.
• Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats.
• Effect of individual amino acids on plasma cholesterol level in rats fed a high cholesterol diet.
• Dietary sulfur-containing amino acids and glycine as determinant factors in plasma cholesterol regulation in growing rats.
• Effect of dietary glycine on methionine metabolism in rats fed a high-methionine diet.
• Self-selection of phenylalanine in the rat.

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