EFFECT OF INDIVIDUAL AMINO ACID SUPPLEMENTS ON THE TOXICITY OF EXCESS TYROSINE IN RATS

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概要

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• The object of this study was to determine the effects of individual amino acid supplements on the development of tyrosine toxicity in growing rats fed 10% casein containing 5% tyrosine. Each amino acid was added at levels equivalent to its content in 20% casein. Supplement of methionine to the high tyrosine diet partially alleviated both growth depression and pathological lesions. Threonine and cystine had a somewhat beneficial effect, but the single addition of other amino acids was not effective. Besides, some amino acids enhanced the severity of the toxicity even more. The effects of methionine supplementation were highest at 0.66 to 1.32 levels (equivalent to the methionine content in 20 to 40% casein). By the supplement of both 0.66 % methionine and 0.90% threonine to the high tyrosine diet, growth was significantly improved and toxic lesions were completely prevented. It was confirmed that the counteracting effects to the toxicity, caused by the extra addition of protein (casein) to rats fed a high tyrosine-low protein diet, were mainly attributed to the effectiveness of the methionine and threonine, i.e., first-and second-limiting amino acids, respectively, contained in it.

• 財団法人 学会誌刊行センターの論文

著者

• 津田 博司

  静岡大農 農化

• 村松 敬一郎

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shiz

• 有藤 隆行

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shiz

• 津田 博司

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shiz

• 村松 敬一郎

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University

• 津田 博司

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University

• 有藤 隆行

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University

• 村松 敬一郎

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture

関連論文

• 7.ラットのチロシン過剰障害に対するアミノ酸添加の影響(JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY : 掲載論文要旨)
• SUPPLEMENTAL EFFECT OF LYSINE ON GROWTH DEPRESSION OF RATS FED WHEAT GLUTEN DIETS CONTAINING EXCESSIVE AMOUNT OF SOME INDIVIDUAL AMINO ACIDS
• THE RELATIONSHIP BETWEEN WEIGHT GAIN AND FREE AMINO ACID CONCENTRATION OF PLASMA AND LIVER IN RATS FED A DIET SUPPLEMENTED WITH VARIOUS AMOUNTS OF LYSINE
• EFFECT OF SUPPLEMENTATION OF LIMITING AMINO ACIDS ON TYROSINE TOXICITY IN RATS FED WHEAT GLUTEN DIETS
• EFFECT OF INDIVIDUAL AMINO ACID SUPPLEMENTS ON THE TOXICITY OF EXCESS TYROSINE IN RATS
• BENEFICIAL EFFECT OF METHIONINE AND THREONINE SUPPLEMENTS ON TYROSINE TOXICITY IN RATS
• Self-selection of histidine and arginine intake and the requirements for these amino acids in growing rats.
• Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.
• Effects of methionine and related compounds on plasma cholesterol level in rats fed a high cholesterol diet.
• Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats.
• Effect of individual amino acids on plasma cholesterol level in rats fed a high cholesterol diet.
• Dietary sulfur-containing amino acids and glycine as determinant factors in plasma cholesterol regulation in growing rats.
• Effect of dietary glycine on methionine metabolism in rats fed a high-methionine diet.
• Self-selection of phenylalanine in the rat.

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