EFFECT OF SUPPLEMENTATION OF LIMITING AMINO ACIDS ON TYROSINE TOXICITY IN RATS FED WHEAT GLUTEN DIETS

概要

論文の詳細を見る
The effect of supplementation of limiting amino acids on rats fed a 10 or 20% wheat gluten diet containing 5% tyrosine has been investigated. Growth-limiting amino acids in a 20% wheat gluten diet were lysine and threonine. When rats were fed a 20% wheat gluten diet containing excess tyrosine, the addition of 1.0% lysine⋅HCl or 1.0% lysine⋅HCl and 0.4% threonine completely prevented the development of tyrosine toxicity, and was accompanied by a lowering of free tyrosine concentrations in plasma, liver and muscle. In rats receiving a 10% wheat gluten diet, lysine, threonine and methionine were limiting for growth. The addition of 1.0% lysine⋅HCl to the 10% wheat gluten plus 5% tyrosine diet failed to alleviate the tyrosine toxicity, but the supplement of 1.0% lysine⋅HCl and 0.4% threonine could partially alleviate the toxicity. The combined addition of 1.0% lysine⋅HCl, 0.4% threonine and 0.5% methionine was most effective. The free tyrosine concen-trations in plasma, liver and muscle were lowered greatly by the supple-mentation of three limiting amino acids, but amounts of free tyrosine and phenolic metabolites excreted in the urine did not decrease with ad-dition of these limiting amino acids.
財団法人学会誌刊行センターの論文