Effect of dietary glycine on methionine metabolism in rats fed a high-methionine diet.

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概要

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• The alleviation mechanism of methionine toxicity by dietary glycine was investigated in weanling rats fed a high-methionine diet. When rats were fed a 10% casein diet containing 2% methionine, the activities of methionine adenosyltransferase, cystathionine β-synthase, and cystathionine y-lyase, which participate in the methionine metabolism in the transsulfuration pathway, were significantly enhanced. But the addition of 2% glycine to the high methionine diet did not cause further increase in these enzyme activities; the activities of methionine adenosyltransferase and cystathionine β-synthase were rather decreased while cystathionine γ-lyase activity was not altered. Methionine transaminase activity was essentially insensitive to the dietary addition of methionine and glycine. In rats fed a high methionine diet, the hepatic methionine level was significantly increased with a concomitant decrease in the levels of glycine, serine, and threonine. The addition of glycine to the high methionine diet effectively suppressed the enhancement of the hepatic methionine level and almost completely restored the glycine level, but it only partially restored the serine level and further decreased the threonine level. From these results, it is suggested that the alleviating effect of dietary glycine on methionine toxicity is primarily elicited by the restoration of the hepatic glycine level rather than by an increase in hepatic enzyme activity.

• 財団法人 学会誌刊行センターの論文

著者

• 村松 敬一郎

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture

• 杉山 公男

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University

• 九島 康夫

  Laboratory of Food and Nutrition, Department of Agricultural Chemistry, Faculty of Agriculture, Shizuoka University

関連論文

• THE RELATIONSHIP BETWEEN WEIGHT GAIN AND FREE AMINO ACID CONCENTRATION OF PLASMA AND LIVER IN RATS FED A DIET SUPPLEMENTED WITH VARIOUS AMOUNTS OF LYSINE
• EFFECT OF SUPPLEMENTATION OF LIMITING AMINO ACIDS ON TYROSINE TOXICITY IN RATS FED WHEAT GLUTEN DIETS
• EFFECT OF INDIVIDUAL AMINO ACID SUPPLEMENTS ON THE TOXICITY OF EXCESS TYROSINE IN RATS
• BENEFICIAL EFFECT OF METHIONINE AND THREONINE SUPPLEMENTS ON TYROSINE TOXICITY IN RATS
• Self-selection of histidine and arginine intake and the requirements for these amino acids in growing rats.
• Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet.
• Effects of methionine and related compounds on plasma cholesterol level in rats fed a high cholesterol diet.
• Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats.
• Effect of individual amino acids on plasma cholesterol level in rats fed a high cholesterol diet.
• Dietary sulfur-containing amino acids and glycine as determinant factors in plasma cholesterol regulation in growing rats.
• Effect of dietary glycine on methionine metabolism in rats fed a high-methionine diet.
• Self-selection of phenylalanine in the rat.

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