Experimental study on disseminated intravascular coagulation(DIC). 1. Experimental model of DIC induced by endotoxin in rabbits and diagnostic criteria for DIC(DIC score).:1. Experimental model of DIC induced by endotoxin in rabbits and diagnostic criteri

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The purpose of the present study is to clarify the disease of disseminated intravascular coagulation (DIC). We designed an experimental model of DIC in rabbits induced by continuous infusion of endotoxin (ET) for three hours. The animals were divide into four groups as follows; Group I: infusion with ET (0.1mg/kg)+physiological saline Group II: infusion with ET (1.0mg/kg)+physiological saline Group III: infusion with ET (3.0mg/kg)+physiological saline Group IV: infusion with physiological saline only (control). Tentative diagnostic criteria for experimental DIC were proposed as DIC score including various blood parameters and pathological findings (micro-clot formation in lung and kidney). The results indicated that aggravations of blood parameters and pathological findings were dependent upon the dose of ET, and Group III made the highest score in on studies. From these results, we may conclude that Group III was considered to be useful as DIC model in rabbits.
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