A case of acute DIC induced during surgical operation for the gingival carcinoma of the mandible.

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A case of disseminated intravascular coagulation syndrome (DIC), which was induced during surgical operation and cured by the prompt treatment, is reported. The patient was a 52-year-old female with gingival carcinoma at the mandible (T2N0M0). Radiation therapy with 60Co (total dose of 30 Gy) and chemotherapy (100 mg pepleomycin. and 60 g tegaful in total dose) were carried out preoperatively. Tumor excision with segmental mandibulectomy, immediate reconstruction of the mandible by use of A-O osteosynthetic plate and radical neck dissection were performed. Close to the end of the surgical procedure, hemorrhagic diathesis arose. Data of laboratory examination immediately after the operation (7.7×104/mm3 of platelets, 33% of prothrombin time and 43 mg/dl of fibrinogen) suggested acute DIC. Heparin, FOY (gabexate mesilate), and FFP were immediatly administrated and then the hemorrhagic diathesis disappeared. Seven weeks were required to cure the chronic DIC completely. At present, the patient is free from recurrence of both DIC and carcinoma.