A case of hemangiopericytoma of the buccal mucosa. An immunohistochemical and ultrastructural study with review of the literature.:An immunohistochemical and ultrastructural study with review of the literature

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A case of hemangiopericytoma of the buccal mucosa in a 54-year-old woman is presented, which brings the total number of such uncommon oral cases of this tumor to 17 in Japanese literature.<BR>The tumor consisted of tightly arranged spindle-shaped cells proliferating inbetween blood capillaries showing an occasional "staghorn" configuration. The perivascular location of tumor cells was clearly revealed by the reticulin stain. Tumor cells were negative for Factor VIIIrelated antigen and devoid of conspicuous positivity for vimentin, in sharp contrast to the intense reaction of capillary endothelial cells to these antigens. The tumor cells shared ultrastructural features with normal pericytes, i.e., the presence of pinocytotic vesicles, bundles of microfilaments with dense bodies and basal lamina-like material. Thus the immunohistochemical and/or ultrastructural examination is regarded useful for differentiating hemangiopericytoma from other tumors with a pericytomatous histological pattern.<BR>This case should be followed carefully, as similar benign-appearing lesions have been reported to recur and/or metastasize occasionally after surgical enucleation.
社団法人日本口腔外科学会の論文