口腔領域扁平上皮癌および白板症における細胞動態ならびにインボルクリンの局在に関する免疫組織化学的検討

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Cell kinetics and distribution of Involucrin in fifteen cases of squamous cell carcinoma (SCC), eleven cases of leukoplakia, and five cases of normal mucosa in the oral region have been detected immunohistocliemically. The cell kinetics were evaluated by identifying the DNA synthetic cells (S-phase cells) by in vitro labelling method using bromodeoxyuridine (BrdU) and its monoclonal antibody. The following results were obtained: 1. BrdU positive cells were localized in one or two layers of the basal cell in both normal and hyperplastic epithelium without atypism. They were also demonstrated in the periphery of cancer nest in highly and moderately differentiated SCC. However, they were scattered diffusely in poorly differentiated SCC. 2. In normal epithelium Involucrin, there were positive to the superior forms of spinous cell layers. In highly and moderately differentiated SCC, Involucrin displayed in the cancer nest with an irregular and patchy pattern. But in poorly differentiated SCC, Involucrin were negative. In spite of the different stain ability of Involucrin between normal epithelium and SCC, the relation between Involucrin-positive cell and BrdU-positive cell was kept both normal epithelium and SCC. 3. The labelling indexes (L. I.) for BrdU were 4.8% in normal epithelium, 7.5% in the hyperplastic one without atypism, and 11.6% in that with atypism, respectively. As the degree of the epithelial dysplasia increased, the L. I. was high. 4. The L. I. was 19.2% in a highly differentiated SCC, 19.5% in the moderate one, and 19.1% in the poor one. There are, however, no correlation between the degree of cell differentiation and the L. I.

口腔領域扁平上皮癌および白板症における細胞動態ならびにインボルクリンの局在に関する免疫組織化学的検討

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