Immunohistochemical detection of microvessels in oral squamous cell carcinomas.

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Thirty-three cases of oral squamous cell carcinoma (S. C. C.) were studied immunohistochemically, using an antibody against vascular endothelium (JC70A). The relationship between the distribution of microvessels and clinicopathological factors was also investigated.<BR>In healthy epithelium, crosssections and the course of microvessels had a regular appearance. However, in S. C. C., microvessels appeared to be irregular and their density was increased.<BR>In highly differentiated S. C. C., microvessels were localized around the cancer nests, but in poorly differentiated S. C. C., microvessels were scattered. The density of microvessels in highly-differentiated S. C. C. was higher than that in poorly differentiated S. C. C. However, no correlation between the density of tumor vessels and tumor proliferation. indicated by T classification and PCNA labelling Index, could be demonstrated.<BR>The relationship between tumor vessel density and the histological grade of the mode of invasion was determined. At the invasive edge of the tumor, tumor vessel density was higher in grades 4C and 4D than in other grades. The vessel density was also higher in tumors with lymphnode metastasis, than in those without lymph node metastasis.<BR>These results suggested that tumor invasion and metastasis may be related to the distribution of tumor vessels.
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