口腔領域に発生した粘表皮癌の免疫組織化学的検討

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This paper deals with cell kinetics and the correlation between proliferating cells and phenotype expression in mucoepidermoid carcinomas. Ten patients who had been treated at the Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, during the last ten years, were selected for this study.<BR>Immunohistochemical studies of proliferating cells and the phenotype of tumor cells were performed using anti-proliferating cell nuclear antigen (PCNA), CEA, muscle actin, S-100, lactoferrin, secretory component and total keratin antibodies.<BR>The PCNA labelling index (L.I.) of mucoepidermoid carcinomas was higher than that of normal salivary gland tissues, and correlated with tumor differentiation.<BR>The proliferating activity of tumor cells in the capsule was little higher than that in the nests of the tumors. Localization of muscle actin, lactoferrin and total keratin was frequently detected in PCNA positive cells, but that of CEA and secretory component was not demonstrated in them.<BR>These results indicated that CEA and secretory component were objective markers for the functional differentiation of mucoepidermoid carcinomas.
社団法人日本口腔外科学会の論文