口腔扁平上皮癌における腫瘍進展度とリンパ節転移に関する病理組織化学ならびに免疫組織化学的研究

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101 cases of squamous cell carcinoma of the oral cavity were investigated in regard to the relationship between tumor extent and (1) lymph node metastasis and (2) histological grading of malignancy.<BR>Immunohistochemical studies with laminin and type IV collagen were also carried out to assess the relationship between tumor extent and lymph node metastasis.<BR>It was suggested that five histological parameters (differentiation, nuclear polymorphism, mitoses, mode of invasion and mononuclear cell infiltration) and the basement membrane distribution pattern were not significantly related with tumor extent.<BR>In contrast, the mode of invasion and the basement membrane distribution pattern were closely correlated with lymph node metastasis.
社団法人日本口腔外科学会の論文