A case of tardive ulcer of the oral mucosa that appeared 17 years after irradiation.

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An 84-year-old woman was referred to us on July 11, 1990 with complaints of dysphagia and a painful ulcer in the right retromolar and tonsillar areas. She had a previoushistory of surgery for tonsillar cancer (squamous cell carcinoma), followed by postoperative<SUP>60</SUP>Co external irradiation to the lateral region of the neck with 50. 8 Gy and implantation of Rn-seeds about 17 years before. The postoperative course had been uneventful without re-currence or metastasis.<BR>Oral findings showed a large ulcer of 30 mm in diameter surrounded by submucosaltumor-lke protrusion in the right retromolar and tonsillar areas. The ulcer including thesurrounding tissue was extirpated because conservative treatment had been in effective. Buthistological examination revealed nonspecific ulcer surrounded by fibrous granulation tissuewith atypical fibroblasts and hyalinization of arterioles.<BR>Based on the patient's clinical findings, previous medical history and histological ex-amination, the lesion was diagnosed as a postradiation ulcer that appeared 17 years afterirradiation.
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