Heterotopic bone formation in the submandibular lymph node - A case report and a review of the literature on mechanism of bone formation. : A case report and a review of the literature on mechanism of bone formation

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A case of submandibular lymphadenitis accompanied by heterotopic bone formation is reported herewith and discussed in terms of the mechanism of bone formation. To the best of our knowledge, no such report of intralymph nodal bone formation could be seen.<BR>The patient was a 43-year-old woman who had noticed the swelling with slight oppressive pain in the left submandibular region about 10 years ago. The swelling was left untreated, however, due to the slight degree of the oppressive pain even though it recurred and then diminished again dozens of times. But when the swelling and the oppressive pain became stronger than before, the patient came to our hospital. Radiographic examination revealed many radio-opaque round images roughly the size of millet or rice seed in the left side of the submandibular region. Histopathological examination revealed matured bony tissue with formed bone marrow in the lymph node.<BR>In the past, many case reports and various experimental studies on heterotopic bone formation have been presented. The authors, however, have merely discribed their own views concerning its onset mechanism, and no established theory has yet resulted.