実験的フッ素中毒ラットにおける造血系酵素の変動について--ALA-DおよびALA-Sの活性変動

概要

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The effect of fluoride poisoning on the activity of two of the eight heme synthetic enzymes, i. e., ALA synthetase (ALA-S) and ALA-dehydrase (ALA-D) in growing rats was investigated. Male rats of the Donryu strain aged 4 weeks were divided into two groups, a control group and a high fluoride diet group. The fluoride rats were given a diet with 2, 4, 6, 8 and 10mg F (as NaF) for four weeks, during which period blood samples were drawn in quantities of about 100μl via the tail vein for determination of ALA-D activity, reticulocyte count, and hematocrit (Ht). At the end of the four-week observation period the animals were sacrificed by exsanguination via the axillary vein and the bone marrow was assayed for ALA-S activity. In the fluoride group, the ALA-D activity in peripheral blood and ALA-S activity in bone marrow increased, There were significant decreases in- the Ht of rats fed high fluoride diets. From these experimental findings, fluoride poisoning is considered to occur in direct association with heme metabolism.
有限責任中間法人日本口腔衛生学会の論文