Alterations of lewis related sugar antigens in gastric atypical epithelial lesions (Adenomas or dysplasia) with relation to their malignant changes. An evaluation by follow-up cases.:An evaluation by follow-up cases

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Alterations of carbohydrate chain antigens were investigated immunoshitochemically in relation to histological malignant changes on 62 cases of gastric actypical epithelial lesions (adenomas) which were diagnosed as Group-III at the first biopsy and then followed up more than one year. Among 7 carbohydrate chain antigens which are related to Lewis antigens, sialyl LeX-i antigen showed the most impressive findings; The positivity percentage of the first biopsy specimens of Group-III was 6%, however, it raised to 33% in the final biopsy specimens of Group-IV, 50% in the resected specimens of border-line lesions, and 67% in the resected specimens of carcinomas. The results indicate that there exsists a close correlation between malignant change of gastric atypical epithelial lesions and alteration of carbohydrate chain in terms of sialylation.
財団法人日本消化器病学会の論文