Gastroduodenal motor dysfunction and plasma motilin concentration in patients with duodenal ulcer.

概要

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Plasma motilin concentration, gastroduodenal motility and pH were investigated simultaneously in eight normal subjects (N) and fourteen patients with duodenal ulcer (DU).The following results were obtained; (1) In N group, plasma motilin increased gradually in phase II correlated with gastroduodenal motility, its peak was associated with the onset of gastric IMC and decreased already in duodenal phase III. (2) In DU group, the incidence of IMC was significantly lower than N, and plasma motilin was not correlated with gastric motility. In several DU patients, motilin peak was appeared without IMC.It was suggested that the increase of plasma motilin was required in order to initiate gastric IMC, but was not the final mediator. The authors concluded that gastroduodenal motor dysfunction in DU was caused by some malajustment mechanisms of gastroduodenal motility except for motilin.
財団法人日本消化器病学会の論文