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The clinical significance of serum group I pepsinigen (PGI) level was evaluated by using PGI radioimmunoassay kit. The mean (±SD) level in 69 healthy control subjects was 48.4±17.6ng per ml and the normal rage (mean±2SD) was considered to be from 13 to 84ng per ml. High serum PGI levels were observed in patients with giant rugae gastritis, multiple gastric ulcers, duodenal ulcer and gastric ulcer, and the mean (±SD) levels were 259.5±135.9 (n=6), 296.6±181.9 (n=5), 96.1±38.2 (n=12) and 77.5±33.0(n=35) ng per ml, respectively. Those were singificantly different from the normal level. In addition, rates of high PGI level above the normal range in these diseases were 100, 80, 50 and 45%, respectively.In 3 patients with pernicious anemia and 11 patients with multiple gastric polyps, serum PGI levels were significantly lower than normal value and the mean (SD) levels were 8.1±1.7 and 25.7±17.2ng per ml, respectively. The lower PGI level in both diseases was considered to reflect the gastric mucosal atrophy detected by an endoscopical examination.In addition, among 43 patients with hypergastrinemia (>150pg/ml), all patients with giant rugae gastritis showed high levels of both serum PGI and serum gastrin.This finding indicates that the measurement of serum PGI is useful for the differential diagnosis between hypergastrinemia accompanied with atrophic and giant rugae gastritis.
財団法人日本消化器病学会の論文