:A Study of 21 Autopsied Cases

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A study of 21 cases with pseudomembranous enterocolitis diagnosed post-mortem was described. The incidence of pseudomembranous enterocolitis in the all necropsies was 3.2% in a 7-year period from 1973 to 1979 in our hospital. The incidence of the disease did not increase significantly during the recent 7 years.As for the abdominal symptoms, diarrhea was noted in 19 cases (90%) and bloody stool was observed in 7 cases (33%). In all 21 cases, various antibiotics has been administered prior to the development of the pseudomembranous enterocolitis. Average interval from the initiation of antibiotic treatment to the onset of abdominal symptoms was 8 days with a range of 1 to 24 days.Microscopically, in 19 cases (90%), lesions were located in the large intestine while in the small intestine, lesions were observed only in 2 cases (10%). The lesion of rectum was seen in 18 cases (86%) and the degree of involvement was generally severe in the anal site.Histologically, the inflammatory changes were confined to mucosal or submucosal layers except one case in which the perforation leading to peritonitis occured at the transverse colon.In 4 cases (19%), serious complications of the pseudomembranous enterocolitis such as sepsis, marked hypoproteinemia and perforative peritonitis were observed.
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