:Especially, the Effect of Cigarette Smoking on the Healing Course of Acetic Acid Ulcer in Rats

概要

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In order to elucidate the effect of cigarette smoking on the gastric mucosa, load with smoking or nicotine administration was given to rats bearing experimental acetic acid ulcer of stomach. The microangiography was performed to measure the diameter of the gastric mucosal vessels. In all groups which were loaded with cigarette smoking, the healing course of acetic acid ulcer was prolonged. Similar result was shown in the groups which were igven subcutaneous injection of nicotine (250μg/kg or 500μg/kg).The results of microangiographic study disclosed that the diameter of metarteriole, precapillary and capillary blood vessels decreased after cigarette smoking as well as nicotine administration, and this contraction persisted for sixty minutes.It is concluded that cigarette smoking.exerts ill influence upon the healing course of the gastric ulcer, and this effect is hypothesized to be due to the reduction of the gastric mucosal blood flow.
財団法人日本消化器病学会の論文