INTRAVENOUS INFUSION OF CARBOHYDRATE AFTER INDUCTION OF ACUTE HEPATIC INJURY BY CCl4 AND ITS EFFECT ON INJURED LIVER

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Intravenous infusion of 5% glucose, 10% maltose or saline to CCl4-injured rabbits was performed 24 hours after administration of the hepatotoxin. Liver function tests were examined on sera obtained at 24 and 48 hours and activities of several enzymes and contents of triglycerides, protein and glycogen were determined on livers obtained at 48 hours together with histological examination of hepatic tissues. The results indicated no essential differences among the above three experimental groups of animals with different treatments in the extent of hepatic injury found at 48 hours.Intravenously infused maltose was partially converted into glucose by intestinal tissues before entering into the liver through the portal vein. Small proportions of maltose was metabolized by the liver via glucose as an intermediate.Utilization of maltose by injured liver slices was reduced as compared with intact liver slices, although the relative rate of glucose utilization to the formation of glucose from maltose was greater in the injured liver than in the control.In conclusion, the intravascularly administered maltose is less likely to aggravate the preexisting hepatic injury, although the curative effect is not expected either once the process of liver damage has started.
財団法人日本消化器病学会の論文