Some Biological Properties of Human Chorionic Follicle Stimulating Hormone
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概要
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The biological properties of human chorionic FSH (hCFSH) for rat ovaries were investigated. Highly purified hCFSH had similar response to the ovarian augmentation test as bovine FSH and significantly enhanced <SUP>3</SUP>H-thymidine uptake by granulosa cells and theca cells in the ovary of hypophysectomized rat. In contrast, highly purified hCG little responded to the ovarian augmentation test and had no effect on <SUP>3</SUP>H-thymidine uptake by the ovary. These results indicate that hCFSH may promote the follicular growth of ovary resulting from granulosa cell proliferation and its enlargement. In addition, freshly harvested porcine granulosa cells were employed in an <I>in vitro</I> system to investigate specific binding of hCFSH to ovarian receptor. Radioiodinated hCFSH (<SUP>125</SUP>I-hCFSH) and hCG (<SUP>125</SUP>I-hCG) were respectively incubated with cell suspensions. Binding of these hormone preparations was proportional to the cell number and increased with the time of incubation through 120 minutes. The binding ability of <SUP>125</SUP>I-hCFSH to the cells was greater than that of <SUP>125</SUP>I-hCG. Increasing concentrations of unlabeled hCFSH in the incubation mixture progressively inhibited the uptake of <SUP>125</SUP>I-hCFSH by granulosa cells. Unlabeled hCG was not able to compete with <SUP>125</SUP>I-hCFSH binding. The similar, phenomenon to inhibit the binding of <SUP>125</SUP>I-hCG to the cells was also recognized in the presence of unlabeled hCG. These findings suggest that granulosa cell has at least two different types of receptor sites: one for hCFSH and the other for hCG.
- 社団法人 日本内分泌学会の論文
著者
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Maruo Takeshi
Department Of Cardiology Kurashiki Central Hospital
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Tojo Shimpei
Department Of Gynecology And Obstetrics Kyoto University School Of Medicine
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Ashitaka Yoshihiko
Department Of Gynecology And Obstetrics Kobe University Faculty Of Medicine
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Nishimoto Hiroyuki
Department Of Applied Chemistry Faculty Of Engineering Ehime University
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NISHIMOTO HIROYUKI
Department of Obstetrics and Gynecology, Kobe University School of Medicine
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